Abnormal functional connectivity of the amygdala is associated with depression in Parkinson's disease.
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338Abnormal functional connectivity of the amygdala is associated with depression in Parkinson's disease.
Auteurs : Xiao Hu [République populaire de Chine] ; Xiaopeng Song ; Yonggui Yuan ; Erfeng Li ; Jiajia Liu ; Weiguo Liu ; Yijun LiuSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Amygdala (pathology), Amygdala (physiopathology), Brain Mapping, Depression (diagnosis), Depression (etiology), Depression (physiopathology), Depressive Disorder (diagnosis), Depressive Disorder (etiology), Depressive Disorder (physiopathology), Emotions (physiology), Female, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Neural Pathways (pathology), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology).
- MESH :
- complications : Parkinson Disease.
- diagnosis : Depression, Depressive Disorder, Parkinson Disease.
- etiology : Depression, Depressive Disorder.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Amygdala, Neural Pathways.
- physiology : Emotions.
- physiopathology : Amygdala, Depression, Depressive Disorder, Parkinson Disease.
- Adult, Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
Depressive symptoms are common in Parkinson's disease (PD), but the pathophysiology and neural basis underlying depression in PD is not well understood. Abnormal functional connectivity of the amygdala with various cortical and subcortical areas has been observed in major depressive disorder, indicating that dysfunction of the corticolimbic network may be involved in the pathogenesis of major depressive disorder. However, little is known about alterations of amygdala functional connectivity in depressed PD patients. In the present study, 20 depressed PD patients, 40 nondepressed PD patients, and 43 matched healthy controls underwent neuropsychological tests and resting-state functional MRI scanning. Between-group differences in amygdala functional connectivity network were examined using t tests. Compared to the nondepressed PD patients, depressed PD patients showed increased left amygdala functional connectivity with the bilateral mediodorsal thalamus, right amygdala functional connectivity with the left superior temporal gyrus, and left calcarine gyrus. Compared to the healthy controls, the depressed PD group also showed increased left amygdala functional connectivity with the bilateral mediodorsal thalamus, but decreased left amygdala functional connectivity with the left putamen, left inferior frontal gyrus, and the right cerebellum, as well as decreased right amygdala functional connectivity with the left inferior orbitofrontal gyrus, the left gyrus rectus, and the right putamen. The increased connectivity between limbic regions and decreased connectivity between the corticolimbic networks may reflect impaired high-order cortical regulatory effects on the emotion-related limbic areas, which may lead to mood dysregulation. Our study should advance the understanding of neural mechanisms underlying depression in PD.
DOI: 10.1002/mds.26087
PubMed: 25545969
Affiliations:
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sort="Li, Erfeng" uniqKey="Li E" first="Erfeng" last="Li">Erfeng Li</name></author><author><name sortKey="Liu, Jiajia" sort="Liu, Jiajia" uniqKey="Liu J" first="Jiajia" last="Liu">Jiajia Liu</name></author><author><name sortKey="Liu, Weiguo" sort="Liu, Weiguo" uniqKey="Liu W" first="Weiguo" last="Liu">Weiguo Liu</name></author><author><name sortKey="Liu, Yijun" sort="Liu, Yijun" uniqKey="Liu Y" first="Yijun" last="Liu">Yijun Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25545969</idno><idno type="pmid">25545969</idno><idno type="doi">10.1002/mds.26087</idno><idno type="wicri:Area/PubMed/Corpus">000300</idno><idno type="wicri:Area/PubMed/Curation">000300</idno><idno type="wicri:Area/PubMed/Checkpoint">000338</idno><idno type="wicri:Area/Ncbi/Merge">004209</idno><idno type="wicri:Area/Ncbi/Curation">004209</idno><idno type="wicri:Area/Ncbi/Checkpoint">004209</idno><idno 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sortKey="Yuan, Yonggui" sort="Yuan, Yonggui" uniqKey="Yuan Y" first="Yonggui" last="Yuan">Yonggui Yuan</name></author><author><name sortKey="Li, Erfeng" sort="Li, Erfeng" uniqKey="Li E" first="Erfeng" last="Li">Erfeng Li</name></author><author><name sortKey="Liu, Jiajia" sort="Liu, Jiajia" uniqKey="Liu J" first="Jiajia" last="Liu">Jiajia Liu</name></author><author><name sortKey="Liu, Weiguo" sort="Liu, Weiguo" uniqKey="Liu W" first="Weiguo" last="Liu">Weiguo Liu</name></author><author><name sortKey="Liu, Yijun" sort="Liu, Yijun" uniqKey="Liu Y" first="Yijun" last="Liu">Yijun Liu</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Amygdala (pathology)</term><term>Amygdala (physiopathology)</term><term>Brain Mapping</term><term>Depression (diagnosis)</term><term>Depression (etiology)</term><term>Depression (physiopathology)</term><term>Depressive Disorder (diagnosis)</term><term>Depressive Disorder (etiology)</term><term>Depressive Disorder (physiopathology)</term><term>Emotions (physiology)</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Neural Pathways (pathology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term><term>Depressive Disorder</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Amygdala</term><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Emotions</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Amygdala</term><term>Depression</term><term>Depressive Disorder</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depressive symptoms are common in Parkinson's disease (PD), but the pathophysiology and neural basis underlying depression in PD is not well understood. Abnormal functional connectivity of the amygdala with various cortical and subcortical areas has been observed in major depressive disorder, indicating that dysfunction of the corticolimbic network may be involved in the pathogenesis of major depressive disorder. However, little is known about alterations of amygdala functional connectivity in depressed PD patients. In the present study, 20 depressed PD patients, 40 nondepressed PD patients, and 43 matched healthy controls underwent neuropsychological tests and resting-state functional MRI scanning. Between-group differences in amygdala functional connectivity network were examined using t tests. Compared to the nondepressed PD patients, depressed PD patients showed increased left amygdala functional connectivity with the bilateral mediodorsal thalamus, right amygdala functional connectivity with the left superior temporal gyrus, and left calcarine gyrus. Compared to the healthy controls, the depressed PD group also showed increased left amygdala functional connectivity with the bilateral mediodorsal thalamus, but decreased left amygdala functional connectivity with the left putamen, left inferior frontal gyrus, and the right cerebellum, as well as decreased right amygdala functional connectivity with the left inferior orbitofrontal gyrus, the left gyrus rectus, and the right putamen. The increased connectivity between limbic regions and decreased connectivity between the corticolimbic networks may reflect impaired high-order cortical regulatory effects on the emotion-related limbic areas, which may lead to mood dysregulation. Our study should advance the understanding of neural mechanisms underlying depression in PD.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Li, Erfeng" sort="Li, Erfeng" uniqKey="Li E" first="Erfeng" last="Li">Erfeng Li</name><name sortKey="Liu, Jiajia" sort="Liu, Jiajia" uniqKey="Liu J" first="Jiajia" last="Liu">Jiajia Liu</name><name sortKey="Liu, Weiguo" sort="Liu, Weiguo" uniqKey="Liu W" first="Weiguo" last="Liu">Weiguo Liu</name><name sortKey="Liu, Yijun" sort="Liu, Yijun" uniqKey="Liu Y" first="Yijun" last="Liu">Yijun Liu</name><name sortKey="Song, Xiaopeng" sort="Song, Xiaopeng" uniqKey="Song X" first="Xiaopeng" last="Song">Xiaopeng Song</name><name sortKey="Yuan, Yonggui" sort="Yuan, Yonggui" uniqKey="Yuan Y" first="Yonggui" last="Yuan">Yonggui Yuan</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Hu, Xiao" sort="Hu, Xiao" uniqKey="Hu X" first="Xiao" last="Hu">Xiao Hu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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